Drug interactions
Enoxaparin + Spironolactone
Severity: Moderate
Enoxaparin and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone production and cause hyperkalemia, which may add to the potassium-sparing effect of spironolactone. The risk is greatest in renal impairment, diabetes and with prolonged use.
What this interaction means in plain words
Enoxaparin and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to mineralocorticoid receptor blockade.
What to do
Monitor serum potassium at baseline and periodically during prolonged enoxaparin therapy, especially with renal impairment. Adjust spironolactone if hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Spironolactone?
MediHelp rates the interaction as moderate. Enoxaparin and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone production and cause hyperkalemia, which may add to the potassium-sparing effect of spironolactone. The risk is greatest in renal impairment, diabetes and with prolonged use.
How serious is the interaction between Enoxaparin and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium at baseline and periodically during prolonged enoxaparin therapy, especially with renal impairment. Adjust spironolactone if hyperkalemia occurs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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