Drug interactions
Enoxaparin + Trandolapril
Severity: Moderate
Enoxaparin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress adrenal aldosterone secretion, which may cause hyperkalemia. Together with an ACE inhibitor the risk is additive, especially in diabetes, renal impairment or prolonged use.
What this interaction means in plain words
Enoxaparin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis added to ACE inhibitor reduction of angiotensin II-driven aldosterone release.
What to do
Monitor serum potassium, particularly if enoxaparin is given for more than a few days or renal function is reduced. Treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Trandolapril?
MediHelp rates the interaction as moderate. Enoxaparin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress adrenal aldosterone secretion, which may cause hyperkalemia. Together with an ACE inhibitor the risk is additive, especially in diabetes, renal impairment or prolonged use.
How serious is the interaction between Enoxaparin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly if enoxaparin is given for more than a few days or renal function is reduced. Treat hyperkalemia if it develops.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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