Drug interactions
Entacapone + Metoclopramide intranasal
Severity: Major
Entacapone and Metoclopramide intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a dopamine antagonist that can worsen Parkinson disease and oppose dopaminergic therapy. Entacapone is used to augment levodopa, so the antiparkinson effect may be lost and extrapyramidal symptoms may worsen.
What this interaction means in plain words
Entacapone and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism by central dopamine D2 receptor blockade.
What to do
Avoid metoclopramide in Parkinson disease; use an antiemetic without central D2 blockade such as domperidone (where available and QT risk is acceptable) or ondansetron.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Adrenaline-articaine + Entacapone Moderate
Frequently asked questions
Can I take Entacapone with Metoclopramide intranasal?
MediHelp rates the interaction as major. Entacapone and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide is a dopamine antagonist that can worsen Parkinson disease and oppose dopaminergic therapy. Entacapone is used to augment levodopa, so the antiparkinson effect may be lost and extrapyramidal symptoms may worsen.
How serious is the interaction between Entacapone and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in Parkinson disease; use an antiemetic without central D2 blockade such as domperidone (where available and QT risk is acceptable) or ondansetron.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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