Drug interactions
Amisulpride + Entacapone
Severity: Major
Amisulpride and Entacapone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride can cause sedation and also opposes dopaminergic therapy, so it may worsen parkinsonian symptoms in patients taking entacapone with levodopa. Additive drowsiness can occur. Amisulpride is generally best avoided in Parkinson's disease.
What this interaction means in plain words
Amisulpride and Entacapone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Entacapone belongs to Central Nervous System.
Why it happens
Dopamine D2 antagonism by amisulpride opposes the dopaminergic effect of levodopa/entacapone, with additive sedation.
What to do
Avoid amisulpride in Parkinson's disease where possible and use an agent with less D2 blockade, such as quetiapine or clozapine, if antipsychotic therapy is needed. Monitor motor function and sedation if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
- Adrenaline-articaine + Entacapone Moderate
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Entacapone?
MediHelp rates the interaction as major. Amisulpride and Entacapone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride can cause sedation and also opposes dopaminergic therapy, so it may worsen parkinsonian symptoms in patients taking entacapone with levodopa. Additive drowsiness can occur. Amisulpride is generally best avoided in Parkinson's disease.
How serious is the interaction between Amisulpride and Entacapone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amisulpride in Parkinson's disease where possible and use an agent with less D2 blockade, such as quetiapine or clozapine, if antipsychotic therapy is needed. Monitor motor function and sedation if the combination cannot be avoided.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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