Drug interactions
Entacapone + Metoclopramide
Severity: Major
Entacapone and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide blocks dopamine D2 receptors and can oppose the dopaminergic therapy used in Parkinson's disease, of which entacapone is an adjunct to levodopa. This may worsen parkinsonian symptoms and reduce the benefit of treatment.
What this interaction means in plain words
Entacapone and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entacapone belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism: central D2 blockade by metoclopramide counteracts the dopaminergic effect enhanced by COMT inhibition.
What to do
Avoid metoclopramide in patients with Parkinson's disease on entacapone/levodopa. Use domperidone or another non-central antiemetic if needed, where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide intranasal Major
- Adrenaline-articaine + Entacapone Moderate
Frequently asked questions
Can I take Entacapone with Metoclopramide?
MediHelp rates the interaction as major. Entacapone and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks dopamine D2 receptors and can oppose the dopaminergic therapy used in Parkinson's disease, of which entacapone is an adjunct to levodopa. This may worsen parkinsonian symptoms and reduce the benefit of treatment.
How serious is the interaction between Entacapone and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in patients with Parkinson's disease on entacapone/levodopa. Use domperidone or another non-central antiemetic if needed, where available.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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