Drug interactions
Entrectinib + Eribulin
Severity: Moderate
Entrectinib and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and eribulin has a similar effect. Combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Entrectinib and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor the QTc during therapy and adjust entrectinib per labeling if it is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Eribulin?
MediHelp rates the interaction as moderate. Entrectinib and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and eribulin has a similar effect. Combined use may raise the risk of torsades de pointes.
How serious is the interaction between Entrectinib and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor the QTc during therapy and adjust entrectinib per labeling if it is prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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