Drug interactions
Entrectinib + Ezogabine
Severity: Major
Entrectinib and Ezogabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QTc interval, and ezogabine has similar effects. The combination may raise the risk of torsades de pointes and other arrhythmias.
What this interaction means in plain words
Entrectinib and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Ezogabine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid combined use if an alternative exists. If both are needed, monitor ECG and electrolytes and reduce or stop entrectinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entrectinib and Ezogabine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ezogabine
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Ezogabine?
MediHelp rates the interaction as major. Entrectinib and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QTc interval, and ezogabine has similar effects. The combination may raise the risk of torsades de pointes and other arrhythmias.
How serious is the interaction between Entrectinib and Ezogabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use if an alternative exists. If both are needed, monitor ECG and electrolytes and reduce or stop entrectinib if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
