Drug interactions
Entrectinib + Fingolimod
Severity: Major
Entrectinib and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and cause bradycardia, and fingolimod also slows heart rate and may affect QT. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Entrectinib and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QTc prolongation and bradycardia.
What to do
Avoid the combination if possible. If both are necessary, monitor ECG and electrolytes and reduce or interrupt entrectinib if QTc prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Fingolimod?
MediHelp rates the interaction as major. Entrectinib and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval and cause bradycardia, and fingolimod also slows heart rate and may affect QT. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Entrectinib and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are necessary, monitor ECG and electrolytes and reduce or interrupt entrectinib if QTc prolongation develops.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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