Drug interactions
Entrectinib + Fluticasone-salmeterol
Severity: Moderate
Entrectinib and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and salmeterol can also prolong QT and lower potassium, particularly at higher doses. Combined use may add to the risk of ventricular arrhythmia, especially with other risk factors.
What this interaction means in plain words
Entrectinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium. Avoid exceeding the recommended salmeterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Entrectinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and salmeterol can also prolong QT and lower potassium, particularly at higher doses. Combined use may add to the risk of ventricular arrhythmia, especially with other risk factors.
How serious is the interaction between Entrectinib and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium. Avoid exceeding the recommended salmeterol dose.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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