Drug interactions
Entrectinib + Foscarnet
Severity: Major
Entrectinib and Foscarnet: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib has been associated with QT prolongation, and foscarnet can also prolong the QT interval and disturb electrolytes. Combined use may raise the risk of torsade de pointes and other serious arrhythmias.
What this interaction means in plain words
Entrectinib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT prolongation, with foscarnet-related electrolyte disturbances increasing susceptibility.
What to do
Avoid the combination where alternatives exist. If both are required, monitor ECG and electrolytes closely and correct any abnormalities, adjusting entrectinib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Foscarnet?
MediHelp rates the interaction as major. Entrectinib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib has been associated with QT prolongation, and foscarnet can also prolong the QT interval and disturb electrolytes. Combined use may raise the risk of torsade de pointes and other serious arrhythmias.
How serious is the interaction between Entrectinib and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist. If both are required, monitor ECG and electrolytes closely and correct any abnormalities, adjusting entrectinib if QTc becomes significantly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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