Drug interactions
Entrectinib + Isoflurane
Severity: Moderate
Entrectinib and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and isoflurane can add to repolarization delay. The combination may increase the chance of ventricular arrhythmia.
What this interaction means in plain words
Entrectinib and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check ECG and correct electrolytes before anesthesia. Monitor the ECG continuously during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Isoflurane?
MediHelp rates the interaction as moderate. Entrectinib and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and isoflurane can add to repolarization delay. The combination may increase the chance of ventricular arrhythmia.
How serious is the interaction between Entrectinib and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct electrolytes before anesthesia. Monitor the ECG continuously during and after the procedure.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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