Drug interactions
Entrectinib + Lofexidine
Severity: Major
Entrectinib and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QTc interval, so combined use increases the chance of torsades de pointes and other ventricular arrhythmias. Bradycardia from lofexidine can further increase this risk.
What this interaction means in plain words
Entrectinib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid co-administration when an alternative exists; otherwise monitor ECG and electrolytes (potassium, magnesium) at baseline and during therapy. Interrupt or reduce the dose if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Lofexidine?
MediHelp rates the interaction as major. Entrectinib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, so combined use increases the chance of torsades de pointes and other ventricular arrhythmias. Bradycardia from lofexidine can further increase this risk.
How serious is the interaction between Entrectinib and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration when an alternative exists; otherwise monitor ECG and electrolytes (potassium, magnesium) at baseline and during therapy. Interrupt or reduce the dose if QTc rises significantly.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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