Drug interactions
Entrectinib + Methadone
Severity: Moderate
Entrectinib and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and together raise the risk of torsades de pointes. The risk is higher with electrolyte abnormalities or structural heart disease.
What this interaction means in plain words
Entrectinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during therapy. Reduce or stop the offending drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Methadone?
MediHelp rates the interaction as moderate. Entrectinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and together raise the risk of torsades de pointes. The risk is higher with electrolyte abnormalities or structural heart disease.
How serious is the interaction between Entrectinib and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during therapy. Reduce or stop the offending drug if QTc becomes markedly prolonged.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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