Drug interactions
Entrectinib + Nilotinib
Severity: Major
Entrectinib and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, so using them together may produce additive effects on cardiac repolarization. This increases the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid concurrent use when possible. If needed, monitor ECG and electrolytes at baseline and regularly, and interrupt or reduce therapy if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Nilotinib?
MediHelp rates the interaction as major. Entrectinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval, so using them together may produce additive effects on cardiac repolarization. This increases the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Entrectinib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If needed, monitor ECG and electrolytes at baseline and regularly, and interrupt or reduce therapy if the QTc becomes markedly prolonged.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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