Drug interactions
Entrectinib + Pimavanserin
Severity: Major
Entrectinib and Pimavanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Entrectinib is also a weak to moderate CYP3A4 inhibitor, which could modestly increase pimavanserin levels. Arrhythmia risk is higher in patients with other QT risk factors.
What this interaction means in plain words
Entrectinib and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible mild CYP3A4 inhibition by entrectinib raising pimavanserin exposure.
What to do
Avoid the combination where possible. If used, obtain a baseline ECG, correct electrolytes and monitor the QTc during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Pimavanserin?
MediHelp rates the interaction as major. Entrectinib and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval. Entrectinib is also a weak to moderate CYP3A4 inhibitor, which could modestly increase pimavanserin levels. Arrhythmia risk is higher in patients with other QT risk factors.
How serious is the interaction between Entrectinib and Pimavanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, obtain a baseline ECG, correct electrolytes and monitor the QTc during therapy.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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