Drug interactions
Entrectinib + Salmeterol
Severity: Moderate
Entrectinib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia.
What this interaction means in plain words
Entrectinib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline and follow-up ECG and correct potassium and magnesium. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Salmeterol?
MediHelp rates the interaction as moderate. Entrectinib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbance or bradycardia.
How serious is the interaction between Entrectinib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECG and correct potassium and magnesium. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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