Drug interactions
Entrectinib + Sunitinib
Severity: Major
Entrectinib and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib and sunitinib can each prolong the QT interval, so the combination may increase the risk of torsades de pointes. The risk is greater with bradycardia, electrolyte abnormalities or existing heart disease.
What this interaction means in plain words
Entrectinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid coadministration where possible. If needed, monitor ECG and electrolytes regularly and interrupt or reduce entrectinib according to labeling if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Sunitinib?
MediHelp rates the interaction as major. Entrectinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib and sunitinib can each prolong the QT interval, so the combination may increase the risk of torsades de pointes. The risk is greater with bradycardia, electrolyte abnormalities or existing heart disease.
How serious is the interaction between Entrectinib and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If needed, monitor ECG and electrolytes regularly and interrupt or reduce entrectinib according to labeling if QTc rises significantly.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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