Drug interactions
Entrectinib + Tetracycline
Severity: Minor
Entrectinib and Tetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline is not an established moderate CYP3A4 inhibitor, so a clinically important rise in entrectinib levels is unlikely. The concern is theoretical.
What this interaction means in plain words
Entrectinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entrectinib belongs to Oncology; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition; not well established for tetracycline.
What to do
No entrectinib dose reduction is needed; monitor QT interval and for entrectinib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Tetracycline?
MediHelp rates the interaction as minor. Entrectinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline is not an established moderate CYP3A4 inhibitor, so a clinically important rise in entrectinib levels is unlikely. The concern is theoretical.
How serious is the interaction between Entrectinib and Tetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No entrectinib dose reduction is needed; monitor QT interval and for entrectinib adverse effects.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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