Drug interactions
Entrectinib + Triptorelin
Severity: Moderate
Entrectinib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and triptorelin may add to this effect through androgen deprivation. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Entrectinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation through different mechanisms.
What to do
Perform ECG and electrolyte monitoring at baseline and during treatment, and correct electrolyte abnormalities. Follow entrectinib labeling for dose reduction or interruption if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Triptorelin?
MediHelp rates the interaction as moderate. Entrectinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and triptorelin may add to this effect through androgen deprivation. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Entrectinib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG and electrolyte monitoring at baseline and during treatment, and correct electrolyte abnormalities. Follow entrectinib labeling for dose reduction or interruption if QTc becomes prolonged.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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