Drug interactions
Epinephrine + Hydrochlorothiazide-losartan
Severity: Moderate
Epinephrine and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine shifts potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss. The combination can lead to clinically significant hypokalemia and arrhythmia risk, mainly with systemic or repeated dosing.
What this interaction means in plain words
Epinephrine and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive lowering of serum potassium via beta-2-mediated cellular uptake and thiazide-induced kaliuresis.
What to do
Monitor serum potassium and cardiac rhythm when epinephrine is given systemically. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Epinephrine and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine shifts potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss. The combination can lead to clinically significant hypokalemia and arrhythmia risk, mainly with systemic or repeated dosing.
How serious is the interaction between Epinephrine and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and cardiac rhythm when epinephrine is given systemically. Correct hypokalemia promptly.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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