Drug interactions
Epinephrine + Ipratropium-salbutamol
Severity: Moderate
Epinephrine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine and salbutamol both stimulate beta-adrenergic receptors, so together they can cause marked tachycardia, arrhythmias, tremor, hypertension and hypokalemia. The risk is higher with systemic epinephrine and in patients with cardiac disease.
What this interaction means in plain words
Epinephrine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive adrenergic receptor stimulation and beta-2 mediated intracellular potassium shift.
What to do
Monitor heart rate, rhythm, blood pressure and serum potassium when both are used. Avoid giving additional salbutamol doses unnecessarily around epinephrine administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Epinephrine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine and salbutamol both stimulate beta-adrenergic receptors, so together they can cause marked tachycardia, arrhythmias, tremor, hypertension and hypokalemia. The risk is higher with systemic epinephrine and in patients with cardiac disease.
How serious is the interaction between Epinephrine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm, blood pressure and serum potassium when both are used. Avoid giving additional salbutamol doses unnecessarily around epinephrine administration.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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