Drug interactions
Epinephrine + Levofloxacin
Severity: Moderate
Epinephrine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can cause hypokalemia and arrhythmias, which may add to the QT-prolonging effect of levofloxacin. The concern is mostly relevant with systemic or repeated high-dose use rather than brief emergency dosing.
What this interaction means in plain words
Epinephrine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Levofloxacin blocks hERG potassium channels, while beta-adrenergic stimulation and epinephrine-induced hypokalemia may further destabilize repolarization.
What to do
Do not delay epinephrine in emergencies such as anaphylaxis. With prolonged infusion, monitor ECG and potassium and correct abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Levofloxacin?
MediHelp rates the interaction as moderate. Epinephrine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can cause hypokalemia and arrhythmias, which may add to the QT-prolonging effect of levofloxacin. The concern is mostly relevant with systemic or repeated high-dose use rather than brief emergency dosing.
How serious is the interaction between Epinephrine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not delay epinephrine in emergencies such as anaphylaxis. With prolonged infusion, monitor ECG and potassium and correct abnormalities.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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