Drug interactions
Epinephrine + Quetiapine
Severity: Moderate
Epinephrine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks alpha-1 adrenergic receptors, which can blunt the pressor effect of epinephrine and leave beta-mediated vasodilation unopposed, resulting in hypotension and reflex tachycardia. This is most relevant when epinephrine is given systemically for anaphylaxis or shock.
What this interaction means in plain words
Epinephrine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Alpha-1 adrenergic blockade by quetiapine opposes epinephrine vasoconstriction, leaving beta-2 vasodilation unopposed.
What to do
Monitor blood pressure and heart rate closely when systemic epinephrine is given; if vasopressor support is needed and hypotension persists, consider norepinephrine or phenylephrine. Epinephrine should still not be withheld in anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Quetiapine?
MediHelp rates the interaction as moderate. Epinephrine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks alpha-1 adrenergic receptors, which can blunt the pressor effect of epinephrine and leave beta-mediated vasodilation unopposed, resulting in hypotension and reflex tachycardia. This is most relevant when epinephrine is given systemically for anaphylaxis or shock.
How serious is the interaction between Epinephrine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when systemic epinephrine is given; if vasopressor support is needed and hypotension persists, consider norepinephrine or phenylephrine. Epinephrine should still not be withheld in anaphylaxis.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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