Drug interactions
Epinephrine + Tolcapone
Severity: Moderate
Epinephrine and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone inhibits COMT, one of the two main enzymes that metabolize catecholamines, so epinephrine effects may be intensified or prolonged. This can lead to higher heart rate, arrhythmias and blood pressure changes.
What this interaction means in plain words
Epinephrine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Tolcapone belongs to Central Nervous System.
Why it happens
Inhibition of catechol-O-methyltransferase reduces the breakdown of epinephrine.
What to do
Monitor heart rate, rhythm and blood pressure when epinephrine is given, and use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Epinephrine with Tolcapone?
MediHelp rates the interaction as moderate. Epinephrine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolcapone inhibits COMT, one of the two main enzymes that metabolize catecholamines, so epinephrine effects may be intensified or prolonged. This can lead to higher heart rate, arrhythmias and blood pressure changes.
How serious is the interaction between Epinephrine and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure when epinephrine is given, and use the lowest effective epinephrine dose.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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