Drug interactions
Tolcapone + Tranylcypromine
Severity: Contraindicated
Tolcapone and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone inhibits COMT, and with a nonselective MAO inhibitor both main catecholamine degradation routes are blocked. This can cause dangerous increases in heart rate and blood pressure, and labeling contraindicates the combination.
What this interaction means in plain words
Tolcapone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tolcapone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Combined COMT and MAO inhibition prevents catecholamine metabolism.
What to do
Do not co-administer. Use an alternative adjunct for parkinsonian therapy if tranylcypromine is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
- Brexpiprazole + Tolcapone Moderate
Frequently asked questions
Can I take Tolcapone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Tolcapone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tolcapone inhibits COMT, and with a nonselective MAO inhibitor both main catecholamine degradation routes are blocked. This can cause dangerous increases in heart rate and blood pressure, and labeling contraindicates the combination.
How serious is the interaction between Tolcapone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative adjunct for parkinsonian therapy if tranylcypromine is needed.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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