Drug interactions
Apomorphine + Tolcapone
Severity: Moderate
Apomorphine and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone inhibits COMT, which contributes to apomorphine metabolism, so apomorphine exposure and effects may increase. This can cause more nausea, hypotension, dyskinesia or hallucinations.
What this interaction means in plain words
Apomorphine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
COMT inhibition by tolcapone reduces catechol metabolism of apomorphine.
What to do
Consider lowering the apomorphine dose when starting tolcapone. Monitor blood pressure and dopaminergic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Asenapine + Tolcapone Moderate
- Brexpiprazole + Tolcapone Moderate
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Tolcapone?
MediHelp rates the interaction as moderate. Apomorphine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolcapone inhibits COMT, which contributes to apomorphine metabolism, so apomorphine exposure and effects may increase. This can cause more nausea, hypotension, dyskinesia or hallucinations.
How serious is the interaction between Apomorphine and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the apomorphine dose when starting tolcapone. Monitor blood pressure and dopaminergic adverse effects.
What other medicines interact with Tolcapone?
MediHelp also lists interactions of Tolcapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Tolcapone page.
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