Drug interactions
Epinephrine racemic + Fosinopril-hydrochlorothiazide
Severity: Moderate
Epinephrine racemic and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can drive potassium into cells and lower serum potassium, adding to thiazide-induced loss. Effects are most relevant with repeated or high-dose use, and epinephrine can also raise blood pressure.
What this interaction means in plain words
Epinephrine racemic and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation causes intracellular potassium shift, additive to thiazide renal potassium loss.
What to do
Monitor serum potassium and blood pressure when epinephrine is used repeatedly or at high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Epinephrine racemic with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Epinephrine racemic and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can drive potassium into cells and lower serum potassium, adding to thiazide-induced loss. Effects are most relevant with repeated or high-dose use, and epinephrine can also raise blood pressure.
How serious is the interaction between Epinephrine racemic and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when epinephrine is used repeatedly or at high doses.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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