Drug interactions
Epinephrine racemic + Hydrochlorothiazide-losartan
Severity: Moderate
Epinephrine racemic and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, particularly with systemic absorption, can lower serum potassium through beta2 stimulation and raise blood pressure. This may add to hydrochlorothiazide-induced hypokalemia and counter antihypertensive effects.
What this interaction means in plain words
Epinephrine racemic and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated intracellular potassium shift adds to thiazide renal potassium loss.
What to do
Monitor serum potassium and blood pressure when repeated or high doses of epinephrine are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Epinephrine racemic with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Epinephrine racemic and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine, particularly with systemic absorption, can lower serum potassium through beta2 stimulation and raise blood pressure. This may add to hydrochlorothiazide-induced hypokalemia and counter antihypertensive effects.
How serious is the interaction between Epinephrine racemic and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when repeated or high doses of epinephrine are used.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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