Drug interactions
Epinephrine racemic + Linezolid
Severity: Major
Epinephrine racemic and Linezolid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate sympathomimetic amines, so racemic epinephrine can produce exaggerated pressor and cardiac effects with linezolid. Hypertension, tachycardia and arrhythmias are possible.
What this interaction means in plain words
Epinephrine racemic and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Linezolid reduces catecholamine degradation by MAO, increasing and prolonging adrenergic effects.
What to do
Avoid unless clinically essential; if used, give the lowest effective dose and monitor blood pressure and heart rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Linezolid?
MediHelp rates the interaction as major. Epinephrine racemic and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors may potentiate sympathomimetic amines, so racemic epinephrine can produce exaggerated pressor and cardiac effects with linezolid. Hypertension, tachycardia and arrhythmias are possible.
How serious is the interaction between Epinephrine racemic and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clinically essential; if used, give the lowest effective dose and monitor blood pressure and heart rhythm.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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