Drug interactions
Epinephrine racemic + Maprotiline
Severity: Major
Epinephrine racemic and Maprotiline: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline potentiates the cardiovascular effects of epinephrine, which can produce marked hypertension, tachycardia and arrhythmias. Both agents can also contribute to QT prolongation.
What this interaction means in plain words
Epinephrine racemic and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of norepinephrine reuptake by maprotiline increases adrenergic response, plus additive QT effects.
What to do
Avoid systemic use where possible and use the lowest effective epinephrine dose. Monitor blood pressure and ECG if co-administration is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Maprotiline?
MediHelp rates the interaction as major. Epinephrine racemic and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline potentiates the cardiovascular effects of epinephrine, which can produce marked hypertension, tachycardia and arrhythmias. Both agents can also contribute to QT prolongation.
How serious is the interaction between Epinephrine racemic and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic use where possible and use the lowest effective epinephrine dose. Monitor blood pressure and ECG if co-administration is unavoidable.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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