Drug interactions
Epinephrine racemic + Procarbazine
Severity: Major
Epinephrine racemic and Procarbazine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate sympathomimetic effects, so racemic epinephrine may cause exaggerated hypertension and tachyarrhythmias. Epinephrine is partly metabolised by MAO, though COMT is also involved.
What this interaction means in plain words
Epinephrine racemic and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases catecholamine availability and potentiates adrenergic pressor responses.
What to do
Use the lowest effective epinephrine dose with blood pressure and heart rate monitoring. Do not withhold in anaphylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Procarbazine?
MediHelp rates the interaction as major. Epinephrine racemic and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate sympathomimetic effects, so racemic epinephrine may cause exaggerated hypertension and tachyarrhythmias. Epinephrine is partly metabolised by MAO, though COMT is also involved.
How serious is the interaction between Epinephrine racemic and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective epinephrine dose with blood pressure and heart rate monitoring. Do not withhold in anaphylaxis.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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