Drug interactions
Epinephrine racemic + Quinidine
Severity: Moderate
Epinephrine racemic and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, mostly used by inhalation or topically, is a sympathomimetic that can provoke tachyarrhythmias and hypokalemia. With quinidine this may add to proarrhythmic risk, but systemic exposure is usually low and a contraindication is not well founded.
What this interaction means in plain words
Epinephrine racemic and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic stimulation and beta-agonist-related hypokalemia may add to quinidine-related repolarization abnormalities.
What to do
Monitor heart rhythm and serum potassium when epinephrine is used systemically or in high doses. Correct electrolyte disturbances promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Quinidine?
MediHelp rates the interaction as moderate. Epinephrine racemic and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine, mostly used by inhalation or topically, is a sympathomimetic that can provoke tachyarrhythmias and hypokalemia. With quinidine this may add to proarrhythmic risk, but systemic exposure is usually low and a contraindication is not well founded.
How serious is the interaction between Epinephrine racemic and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and serum potassium when epinephrine is used systemically or in high doses. Correct electrolyte disturbances promptly.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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