Drug interactions
Epinephrine racemic + Thioridazine
Severity: Moderate
Epinephrine racemic and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can provoke arrhythmias and, with phenothiazines such as thioridazine, alpha-blockade may cause paradoxical hypotension through unopposed beta-stimulation. Thioridazine's QT prolongation may add to the arrhythmic risk, though racemic epinephrine inhalation has low systemic exposure.
What this interaction means in plain words
Epinephrine racemic and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thioridazine's alpha-adrenergic blockade blunts epinephrine's pressor effect while both agents add to cardiac arrhythmia risk.
What to do
Monitor blood pressure and heart rhythm when racemic epinephrine is given, and use the lowest effective dose. If hypotension occurs, use a pure alpha-agonist such as norepinephrine rather than more epinephrine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Thioridazine?
MediHelp rates the interaction as moderate. Epinephrine racemic and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can provoke arrhythmias and, with phenothiazines such as thioridazine, alpha-blockade may cause paradoxical hypotension through unopposed beta-stimulation. Thioridazine's QT prolongation may add to the arrhythmic risk, though racemic epinephrine inhalation has low systemic exposure.
How serious is the interaction between Epinephrine racemic and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm when racemic epinephrine is given, and use the lowest effective dose. If hypotension occurs, use a pure alpha-agonist such as norepinephrine rather than more epinephrine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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