Drug interactions
Epinephrine racemic + Ziprasidone
Severity: Moderate
Epinephrine racemic and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a sympathomimetic that can provoke tachycardia and arrhythmia, and adrenergic stimulation may worsen QT-related risk. Ziprasidone's alpha-blocking activity may also blunt the pressor response, so the combination is generally of limited relevance with inhaled use.
What this interaction means in plain words
Epinephrine racemic and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic stimulation adds to ziprasidone's repolarization effects, and ziprasidone's alpha-blockade may oppose the pressor effect.
What to do
Use the lowest effective epinephrine dose and monitor heart rate, blood pressure and ECG in patients with other QT risk factors. Correct hypokalemia and hypomagnesemia beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Ziprasidone?
MediHelp rates the interaction as moderate. Epinephrine racemic and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine is a sympathomimetic that can provoke tachycardia and arrhythmia, and adrenergic stimulation may worsen QT-related risk. Ziprasidone's alpha-blocking activity may also blunt the pressor response, so the combination is generally of limited relevance with inhaled use.
How serious is the interaction between Epinephrine racemic and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective epinephrine dose and monitor heart rate, blood pressure and ECG in patients with other QT risk factors. Correct hypokalemia and hypomagnesemia beforehand.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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