Drug interactions
Epirubicin + Olaparib
Severity: Moderate
Epirubicin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause bone marrow suppression, and combining them may increase the depth and duration of cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
What this interaction means in plain words
Epirubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epirubicin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from DNA-damaging cytotoxicity and PARP inhibition.
What to do
Monitor complete blood counts frequently and interrupt or reduce doses for significant cytopenias. Provide supportive care as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epirubicin
- Adenovirus types 4 and 7 live + Epirubicin Contraindicated
- Belatacept + Epirubicin Major
- Cimetidine + Epirubicin Major
- Deferiprone + Epirubicin Major
- Dengue vaccine + Epirubicin Major
- Epirubicin + Etrasimod Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Epirubicin with Olaparib?
MediHelp rates the interaction as moderate. Epirubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause bone marrow suppression, and combining them may increase the depth and duration of cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
How serious is the interaction between Epirubicin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and interrupt or reduce doses for significant cytopenias. Provide supportive care as needed.
What other medicines interact with Epirubicin?
MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.
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