Drug interactions
Epoprostenol + Flurbiprofen
Severity: Moderate
Epoprostenol and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation, and flurbiprofen also impairs platelet function. Combined use may increase the risk of bleeding.
What this interaction means in plain words
Epoprostenol and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects through different pathways.
What to do
Monitor for bleeding signs and avoid unnecessary NSAID use during epoprostenol therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Flurbiprofen?
MediHelp rates the interaction as moderate. Epoprostenol and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation, and flurbiprofen also impairs platelet function. Combined use may increase the risk of bleeding.
How serious is the interaction between Epoprostenol and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and avoid unnecessary NSAID use during epoprostenol therapy.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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