Drug interactions
Epoprostenol + Garlic
Severity: Moderate
Epoprostenol and Garlic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol potently inhibits platelet aggregation, and garlic supplements may add mild antiplatelet effects. This may increase bleeding risk, although the effect is theoretical.
What this interaction means in plain words
Epoprostenol and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Garlic belongs to Gastrointestinal Tract.
Why it happens
Additive antiplatelet effects: epoprostenol raises platelet cAMP while garlic constituents inhibit aggregation.
What to do
Avoid garlic supplements where practical and monitor for bleeding. Stop supplements before procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Garlic?
MediHelp rates the interaction as moderate. Epoprostenol and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol potently inhibits platelet aggregation, and garlic supplements may add mild antiplatelet effects. This may increase bleeding risk, although the effect is theoretical.
How serious is the interaction between Epoprostenol and Garlic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid garlic supplements where practical and monitor for bleeding. Stop supplements before procedures.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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