Drug interactions
Epoprostenol + Lofexidine
Severity: Moderate
Epoprostenol and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate through central alpha-2 agonism, while epoprostenol is a potent vasodilator. Together they may cause excessive hypotension, and bradycardia or syncope may follow.
What this interaction means in plain words
Epoprostenol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects: central sympatholytic action of lofexidine plus direct prostacyclin-mediated vasodilation.
What to do
Monitor blood pressure and heart rate closely, especially when starting or changing doses. Reduce the dose of either drug if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Lofexidine?
MediHelp rates the interaction as moderate. Epoprostenol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate through central alpha-2 agonism, while epoprostenol is a potent vasodilator. Together they may cause excessive hypotension, and bradycardia or syncope may follow.
How serious is the interaction between Epoprostenol and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, especially when starting or changing doses. Reduce the dose of either drug if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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