Drug interactions
Epoprostenol + Meclofenamic acid
Severity: Moderate
Epoprostenol and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent inhibitor of platelet aggregation and meclofenamic acid also impairs platelet function and can irritate the gastrointestinal tract. Combined use may increase the risk of bleeding.
What this interaction means in plain words
Epoprostenol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-receptor-mediated platelet inhibition plus NSAID COX-1 inhibition.
What to do
Monitor for signs of bleeding, including gastrointestinal bleeding, and check hemoglobin if symptoms arise. Consider an alternative analgesic such as paracetamol if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Meclofenamic acid?
MediHelp rates the interaction as moderate. Epoprostenol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent inhibitor of platelet aggregation and meclofenamic acid also impairs platelet function and can irritate the gastrointestinal tract. Combined use may increase the risk of bleeding.
How serious is the interaction between Epoprostenol and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, including gastrointestinal bleeding, and check hemoglobin if symptoms arise. Consider an alternative analgesic such as paracetamol if feasible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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