Drug interactions
Epoprostenol + Minoxidil
Severity: Moderate
Epoprostenol and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent short-acting vasodilator, and combining it with minoxidil may cause excessive hypotension. Reflex tachycardia, flushing and dizziness may be more pronounced. Oral minoxidil is a strong vasodilator, so the additive effect can be clinically significant.
What this interaction means in plain words
Epoprostenol and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Minoxidil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor activation and potassium channel opening by minoxidil.
What to do
Monitor blood pressure and heart rate closely during epoprostenol initiation and dose changes. Lower the minoxidil dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minoxidil
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Minoxidil?
MediHelp rates the interaction as moderate. Epoprostenol and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent short-acting vasodilator, and combining it with minoxidil may cause excessive hypotension. Reflex tachycardia, flushing and dizziness may be more pronounced. Oral minoxidil is a strong vasodilator, so the additive effect can be clinically significant.
How serious is the interaction between Epoprostenol and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during epoprostenol initiation and dose changes. Lower the minoxidil dose if hypotension develops.
What other medicines interact with Minoxidil?
MediHelp also lists interactions of Minoxidil with, for example, Aldesleukin, Amifostine, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Minoxidil page.
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