Drug interactions
Avanafil + Minoxidil
Severity: Moderate
Avanafil and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Minoxidil is a potent direct arteriolar vasodilator, and avanafil adds further vasodilation. Significant hypotension is possible.
What this interaction means in plain words
Avanafil and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Minoxidil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Confirm blood pressure is stable before starting avanafil, use the lowest dose, and monitor blood pressure and symptoms of hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Minoxidil
Frequently asked questions
Can I take Avanafil with Minoxidil?
MediHelp rates the interaction as moderate. Avanafil and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Minoxidil is a potent direct arteriolar vasodilator, and avanafil adds further vasodilation. Significant hypotension is possible.
How serious is the interaction between Avanafil and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm blood pressure is stable before starting avanafil, use the lowest dose, and monitor blood pressure and symptoms of hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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