Drug interactions
Epoprostenol + Naproxen
Severity: Moderate
Epoprostenol and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation and naproxen impairs platelet function, so concurrent use increases bleeding risk. This is most relevant in patients with other bleeding risk factors.
What this interaction means in plain words
Epoprostenol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Naproxen belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-mediated inhibition of aggregation plus COX inhibition.
What to do
Monitor for signs of bleeding and avoid unnecessary NSAID use in patients on epoprostenol. Check hemoglobin if bleeding is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Naproxen?
MediHelp rates the interaction as moderate. Epoprostenol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation and naproxen impairs platelet function, so concurrent use increases bleeding risk. This is most relevant in patients with other bleeding risk factors.
How serious is the interaction between Epoprostenol and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and avoid unnecessary NSAID use in patients on epoprostenol. Check hemoglobin if bleeding is suspected.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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