Drug interactions
Epoprostenol + Spironolactone
Severity: Minor
Epoprostenol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, so combining them may cause additive hypotension. This is most relevant in patients with pulmonary hypertension who are volume depleted or have right heart failure.
What this interaction means in plain words
Epoprostenol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epoprostenol belongs to Genitourinary; Spironolactone belongs to Cardiovascular.
Why it happens
Epoprostenol causes direct vasodilation while spironolactone reduces intravascular volume, producing additive blood pressure lowering.
What to do
Monitor blood pressure and volume status, especially when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Spironolactone?
MediHelp rates the interaction as minor. Epoprostenol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can lower blood pressure, so combining them may cause additive hypotension. This is most relevant in patients with pulmonary hypertension who are volume depleted or have right heart failure.
How serious is the interaction between Epoprostenol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status, especially when starting or adjusting either drug.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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