Drug interactions
Epoprostenol + Triamterene
Severity: Minor
Epoprostenol and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator that lowers blood pressure, and triamterene can also contribute to blood pressure reduction through diuresis. Using them together may produce additive hypotension, particularly in volume-depleted patients.
What this interaction means in plain words
Epoprostenol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epoprostenol belongs to Genitourinary; Triamterene belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from vasodilation and diuresis-related volume reduction.
What to do
Monitor blood pressure and volume status when starting or adjusting either drug. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Triamterene?
MediHelp rates the interaction as minor. Epoprostenol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epoprostenol is a potent vasodilator that lowers blood pressure, and triamterene can also contribute to blood pressure reduction through diuresis. Using them together may produce additive hypotension, particularly in volume-depleted patients.
How serious is the interaction between Epoprostenol and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or adjusting either drug. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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