Drug interactions
Eprosartan + Flurbiprofen
Severity: Moderate
Eprosartan and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs blunt the blood-pressure-lowering effect of angiotensin receptor blockers and, by constricting the afferent renal arteriole while the ARB dilates the efferent one, can reduce glomerular filtration and cause acute kidney injury. Hyperkalemia may also occur, and the risk is highest in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Eprosartan and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins opposes angiotensin receptor blockade, reducing renal perfusion and antihypertensive effect.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID. Avoid the combination in volume-depleted or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Flurbiprofen?
MediHelp rates the interaction as moderate. Eprosartan and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs blunt the blood-pressure-lowering effect of angiotensin receptor blockers and, by constricting the afferent renal arteriole while the ARB dilates the efferent one, can reduce glomerular filtration and cause acute kidney injury. Hyperkalemia may also occur, and the risk is highest in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Eprosartan and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID. Avoid the combination in volume-depleted or renally impaired patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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