Drug interactions
Eprosartan + Hydrochlorothiazide-valsartan
Severity: Major
Eprosartan and Hydrochlorothiazide-valsartan: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan and valsartan are both angiotensin receptor blockers, so combining them duplicates therapy. This increases the risk of hypotension, hyperkalemia and renal impairment without added benefit.
What this interaction means in plain words
Eprosartan and Hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Duplicate blockade of the angiotensin II type 1 receptor increases hypotensive and potassium-retaining effects.
What to do
Avoid using two ARBs together and use only one. If this combination was given, stop one agent and check blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eprosartan 300mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: angiotensin II receptor blockers; "dual blockade of the reninangiotensinaldosteronesystem (RAAS) through the combined use of ACEinhibitors, angiotensin II receptor blockers or aliskiren") — electronic medicines compendium (UK SmPC)
Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as major. Eprosartan and Hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan and valsartan are both angiotensin receptor blockers, so combining them duplicates therapy. This increases the risk of hypotension, hyperkalemia and renal impairment without added benefit.
How serious is the interaction between Eprosartan and Hydrochlorothiazide-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together and use only one. If this combination was given, stop one agent and check blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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