Drug interactions
Eprosartan + Ibuprofen
Severity: Moderate
Eprosartan and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs weaken the antihypertensive effect of angiotensin receptor blockers and, together, can cause acute kidney injury and hyperkalemia. The risk is greatest in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Eprosartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins while the ARB reduces efferent arteriolar tone, lowering glomerular filtration and potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Avoid prolonged use, especially in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Ibuprofen?
MediHelp rates the interaction as moderate. Eprosartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs weaken the antihypertensive effect of angiotensin receptor blockers and, together, can cause acute kidney injury and hyperkalemia. The risk is greatest in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Eprosartan and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Avoid prolonged use, especially in high-risk patients.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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