Drug interactions
Eprosartan + Tolvaptan
Severity: Moderate
Eprosartan and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is an aquaretic that does not typically cause potassium retention, though labeling notes serum potassium may rise and should be monitored, particularly alongside potassium-raising drugs. Eprosartan reduces renal potassium excretion, so the combination may add to hyperkalemia risk, and rapid fluid loss may also cause hypotension.
What this interaction means in plain words
Eprosartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Angiotensin receptor blockade reduces potassium excretion while tolvaptan-related volume loss and hemoconcentration may further raise potassium.
What to do
Monitor serum potassium, sodium and volume status after initiation. Adjust therapy if hyperkalemia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Eprosartan with Tolvaptan?
MediHelp rates the interaction as moderate. Eprosartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan is an aquaretic that does not typically cause potassium retention, though labeling notes serum potassium may rise and should be monitored, particularly alongside potassium-raising drugs. Eprosartan reduces renal potassium excretion, so the combination may add to hyperkalemia risk, and rapid fluid loss may also cause hypotension.
How serious is the interaction between Eprosartan and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and volume status after initiation. Adjust therapy if hyperkalemia or hypotension develops.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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