Drug interactions
Eprosartan + Valsartan
Severity: Major
Eprosartan and Valsartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are angiotensin II receptor blockers, so combining them duplicates therapy. Dual use adds hypotension, hyperkalemia and renal impairment risk without proven benefit.
What this interaction means in plain words
Eprosartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade increases effects on blood pressure, aldosterone and renal hemodynamics.
What to do
Avoid combining two angiotensin receptor blockers and use a single agent at an optimized dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Valsartan?
MediHelp rates the interaction as major. Eprosartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are angiotensin II receptor blockers, so combining them duplicates therapy. Dual use adds hypotension, hyperkalemia and renal impairment risk without proven benefit.
How serious is the interaction between Eprosartan and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two angiotensin receptor blockers and use a single agent at an optimized dose.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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