Drug interactions
Eprosartan-hydrochlorothiazide + Flurbiprofen
Severity: Moderate
Eprosartan-hydrochlorothiazide and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can blunt the blood pressure lowering effect of an ARB and thiazide combination. In combination with a diuretic and an ARB it also raises the risk of acute kidney injury, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, which opposes antihypertensive effects and impairs glomerular perfusion when angiotensin II blockade and diuresis are also present.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Flurbiprofen?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can blunt the blood pressure lowering effect of an ARB and thiazide combination. In combination with a diuretic and an ARB it also raises the risk of acute kidney injury, especially in elderly or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where suitable.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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